![]() ![]() Propagated from cell to cell via their interconnections (gap junctions). ![]() In other words, action potentials initiated in any of these cells will be conducted from cell to cell in either direction.Īs noted above, not all cells elicit the same types of action potentials, even though excitation is ![]() Eventually all adjoining cells will depolarize. This then resulted in the spread of depolarization of adjacent cells, in both directions, through cell-to-cell conduction via the gap junctions (nexus). The initial depolarization that occurred within the centrally located cell was induced via a pacemaker lead (fixated into the cell). Shown are several cardiac myocytes in different states of excitation. Identified within the various populations of myocytes (see below).įigure 5. There are several different isoforms of connexins that can be The electrical connections (low resistance pathways, gap junctions)īetween the myocytes are via the channels formed by the protein connexin. The firm mechanical connections are created between the adjacentĬell membranes by proteins. More specifically, the disks join the cells together by both mechanicalĪttachment and protein channels. Intercalated discs are the gap junctions, which allow action potentials to directly spread from one These are irregular transverse thickenings of the sarcolemma, within which thereĪre desmosomes that hold the cells together and to which the myofibrils are attached. In the heart, cardiac muscle cells (myocytes) are connected end to end by structures known as ![]()
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